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Article

Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin.

Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2006

Kobielak Agnieszka, Fuchs Elaine

Abstract excerpt

Cancers display a diverse set of cellular defects, which are thought to be elicited by multiple genetic mutations. In this study, we show that when a single adherens junction protein, alpha-catenin, is removed by conditional targeting, the entire skin epidermis systematically transforms to a hyperproliferative, invasive tissue replete with inflammation. Transcriptional profiling and biochemical analyses reveal...

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Share to alpha Catenin
Share to Carcinoma, Squamous Cell
Share to Neoplasm Invasiveness

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Neovascularization, Physiologic

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Source

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Identifiers

PMID: 16452166
DOI: 10.1073/pnas.0510422103
PMCID: PMC1413714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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