Article
Gene targeting of envoplakin, a cytoskeletal linker protein and precursor of the epidermal cornified envelope.
Molecular and cellular biology - 1 Oct 2001
Määttä A, DiColandrea T, Groot K, Watt F M
Abstract excerpt
Envoplakin, a member of the plakin family of cytoskeletal linker proteins, is localized in desmosomes of stratified epithelial cells and is a component of the epidermal cornified envelope. Gene targeting in mouse embryonic stem cells was used to generate a null allele of envoplakin. No envoplakin transcripts from the targeted allele could be detected in the skin of newborn mice. Mice homozygous for the targeted...
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