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Article

p120-catenin binding masks an endocytic signal conserved in classical cadherins.

The Journal of cell biology - 15 Oct 2012

Nanes Benjamin A, Chiasson-MacKenzie Christine, Lowery Anthony M, Ishiyama Noboru, Faundez Victor, Ikura Mitsuhiko, Vincent Peter A, Kowalczyk Andrew P

Abstract excerpt

p120-catenin (p120) binds to the cytoplasmic tails of classical cadherins and inhibits cadherin endocytosis. Although p120 regulation of cadherin internalization is thought to be important for adhesive junction dynamics, the mechanism by which p120 modulates cadherin endocytosis is unknown. In this paper, we identify a dual-function motif in classical cadherins consisting of three highly conserved acidic residues...

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Identifiers

PMID: 23071156
DOI: 10.1083/jcb.201205029
PMCID: PMC3471230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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