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Periplakin Gene Targeting Reveals a Constituent of the Cornified Cell Envelope Dispensable for Normal Mouse Development

29 Jun 2004

Abstract excerpt

The members of the plakin family of proteins serve as epidermal cytolinkers and components of cell-cell and cell-matrix adhesion complexes, i.e., desmosomes and hemidesmosomes, respectively. Periplakin is a recently characterized member of this family. Human and mouse periplakin genomic loci are conserved, and the proteins are highly homologous, suggesting a role for periplakin in vertebrate physiology. In order...

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PMID: 15226441
DOI: 10.1128/mcb.24.14.6410-6418.2004

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Periplakin Gene Targeting Reveals a Constituent of the Cornified Cell Envelope Dispensable for Normal Mouse DevelopmentPMID 15226441Read ↗

Epiplakin is dispensable for skin barrier function and for integrity of keratin network cytoarchitecture in simple and stratified epithelia.Semantic proximity Read ↗

Gene targeting of envoplakin, a cytoskeletal linker protein and precursor of the epidermal cornified envelope.Semantic proximity Read ↗

Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrierSemantic proximity Read ↗

Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentinSemantic proximity Read ↗

Interaction of periplakin and envoplakin with intermediate filamentsSemantic proximity Read ↗

Plakins, a versatile family of cytolinkers: roles in skin integrity and in human diseases.Semantic proximity Read ↗

Cytolinker cross-talk: Periplakin N-terminus interacts with plectin to regulate keratin organisation and epithelial migrationSemantic proximity Read ↗

Analysis of the desmoplakin gene reveals striking conservation with other members of the plakin family of cytolinkers.Semantic proximity Read ↗

Embryonic heart and skin defects in mice lacking plakoglobin.Semantic proximity Read ↗

Epiplakin, a Novel Member of the Plakin Family Originally Identified as a 450-kDa Human Epidermal AutoantigenSemantic proximity Read ↗

Multiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange Syndrome.Semantic proximity Read ↗

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