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Article

Estimating in silico causal effects of DNA methylation on gene expression through genetic anchors in airway epithelium in asthma.

Science advances - 24 Apr 2026

Kim Soyeon, Caldino Bohn Rebecca I, Sriram Aditya, Park Hyun Jung, Huang Ziyu, Chen Wei, Celedón Juan C

Abstract excerpt

Expression quantitative trait methylation (eQTM) analyses have identified numerous associations between DNA methylation (DNAm) and gene expression, but the causal pathways underlying such associations remain poorly understood. Using single-nucleotide polymorphisms (SNPs) as genetic anchors, we examined potential causal effects between DNAm and gene expression in cis and trans associations in nasal epithelial...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42018614
DOI: 10.1126/sciadv.ady3555
PMCID: PMC13101850

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