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Article

Pathway-level epigenetic modeling illuminates the methylation architecture to asthma risk across tissues.

Epigenetics & chromatin - 19 Jun 2026

Huang Zhongting, Liu Yuxin, Cai Fuqiang, Zhu Jijun, Wang Shenghan, Li Pan, Zhang Shunjie, Song Zhijian, Liu Weixin, Liu Huayong, Chen Junfang

Abstract excerpt

BACKGROUND: Asthma is a clinically heterogeneous airway disorder characterized by complex interactions between environmental exposures, immune activation, and molecular regulatory programs, whose underlying mechanisms are not fully elucidated by known genetic loci. DNA methylation serves as a mechanistic interface bridging genetic predisposition and environmental influences; however, most epigenetic studies...

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Topics

Humans
Asthma
DNA Methylation
Epigenesis, Genetic
Female
CpG Islands

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Genetic Predisposition to Disease

Source

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Identifiers

PMID: 42321852
DOI: 10.1186/s13072-026-00685-y
PMCID: PMC13528033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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