Article
Mediation of Polygenic Asthma Risk Through Gene Expression.
Allergy - 1 Apr 2026
Natarajan Rakesh, Szczesny Brooke, Kanchan Kanika, Esquinca Erika, Boorgula Meher Preethi, Chavan Sameer, Campbell Monica, Lorizio Wendy, Doumatey Ayo P, Cruz Alvaro A, Watson Harold, Naureckas Edward T, Giles B Louise, Arinola Ganiyu, Sogaolu Olumide, Falade Adegoke G, Hansel Nadia N, Olopade Christopher O, Rotimi Charles N, Landis R Clive, Figueiredo Camila A, Kenny Eimear E, Ruczinski Ingo, Liu Andrew H, Ober Carole, Taub Margaret A, Johnson Randi K, Barnes Kathleen C, Wojcik Genevieve L, Mathias Rasika A
Abstract excerpt
BACKGROUND: Existing asthma polygenic risk scores (PRSs) have minimal validation in African-ancestry populations, leaving gaps in our understanding of the wide applicability of PRSs. To widen our understanding of the applicability of asthma PRSs, we apply published PRSs in African-ancestry individuals and quantify the extent to which the PRS-asthma relationship is mediated by clinical biomarkers and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.