Article

Methyl-TWAS: A powerful method for <i>in silico</i> transcriptome-wide association studies (TWAS) using long-range DNA methylation

2023-11-15

Abstract excerpt

<h4>ABSTRACT</h4> In silico transcriptome-wide association studies (TWAS) are commonly used to test whether expression of specific genes is linked to a complex trait. However, genotype-based in silico TWAS such as PrediXcan, exhibit low prediction accuracy for a majority of genes because genotypic data lack tissue- and disease-specificity and are not affected by the environment. Because methylation is tissue-spe...

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Literature Corpus work: ae0a7fc8-5659-587b-9f9b-66c10930074e
DOI: 10.1101/2023.11.10.566586

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