Article
MOSES: a methylation-based gene association approach for unveiling environmentally regulated genes linked to a trait or disease.
Clinical epigenetics - 18 Nov 2024
Kim Soyeon, Qin Yidi, Park Hyun Jung, Bohn Rebecca I Caldino, Yue Molin, Xu Zhongli, Forno Erick, Chen Wei, Celedón Juan C
Abstract excerpt
BACKGROUND: DNA methylation is a critical regulatory mechanism of gene expression, influencing various human diseases and traits. While traditional expression quantitative trait loci (eQTL) studies have helped elucidate the genetic regulation of gene expression, there is a growing need to explore environmental influences on gene expression. Existing methods such as PrediXcan and FUSION focus on genotype-based...
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