Article
DNA methylation in lung cells is associated with asthma endotypes and genetic risk.
JCI insight - 8 Dec 2016
Nicodemus-Johnson Jessie, Myers Rachel A, Sakabe Noburu J, Sobreira Debora R, Hogarth Douglas K, Naureckas Edward T, Sperling Anne I, Solway Julian, White Steven R, Nobrega Marcelo A, Nicolae Dan L, Gilad Yoav, Ober Carole
Abstract excerpt
The epigenome provides a substrate through which environmental exposures can exert their effects on gene expression and disease risk, but the relative importance of epigenetic variation on human disease onset and progression is poorly characterized. Asthma is a heterogeneous disease of the airways, for which both onset and clinical course result from interactions between host genotype and environmental exposures,...
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