Article
Clinical potential of whole-genome data linked to mortality statistics in patients with breast cancer in the UK: a retrospective analysis.
The Lancet. Oncology - 1 Nov 2025
Black Daniella, Davies Helen Ruth, Koh Gene Ching Chiek, Chmelova Lucia, Cubric Marko, Chalivelaki Chan Georgia, Degasperi Andrea, Czarnecki Jan, Toong Ping Jing, Memari Yasin, Whitworth James, Zhao Salome Jingchen, Kumar Yogesh, Basyuni Shadi, Rinaldi Giuseppe, Shooter Scott, Dembrovskyi Vladyslav, Davies Rosie, Chatzou Dunford Maria, Copson Ellen, Palmieri Carlo, Borg Åke, Ambrose John, Bunce Catey, Sosinsky Alona, Arumugam Prabhu, Brown Matthew Arthur, Staaf Johan, Turner Nicholas, Nik-Zainal Serena
Abstract excerpt
BACKGROUND: Breast cancer is the most frequently diagnosed cancer in women. Survival is generally considered favourable, yet some patients remain at risk of early death. We aimed to assess whether comprehensive whole-genome sequencing (WGS) linked to mortality data could add prognostic value to existing clinical measures and identify patients who might respond to targeted therapeutics. METHODS: In this...
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