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Article

Spatial Integration of Protein and Chromosomal States Reveals Early Copy-Number Changes and Genotype-Associated Immune Neighborhoods in Serous Ovarian Cancer Evolution.

Cancer discovery - 1 Sept 2026

Kader Tanjina, Chen Yu-An, Hug Clemens B, Lin Jia-Ren, Muhlich Jeremy L, Coy Shannon, Jung Euihye, Schwartz Lauren E, Fazio Thomas, Chiu Crystal, Ryall Scott T, Drescher Charles W, Sorger Peter K, Drapkin Ronny, Santagata Sandro

Abstract excerpt

Detecting chromosomal copy-number alterations together with protein-defined cell states in intact tissue is critical for understanding early clonal evolution and microenvironmental interactions in cancer. We developed ORION-FISH, which integrates high-plex tissue imaging with a morphology-preserving DNA fluorescence in situ hybridization (DNA-FISH) workflow and single-cell registration, yielding measurements...

Read the complete abstract on PubMed

Topics

Female
Humans
Ovarian Neoplasms
DNA Copy Number Variations
Cystadenocarcinoma, Serous

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

In Situ Hybridization, Fluorescence

Genotype

Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 41999663
DOI: 10.1158/2159-8290.CD-26-0171
PMCID: PMC13530990

Genes

CCNE1
MYC
MDM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

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