A cell-of-origin epigenetic tracer reveals clinically distinct subtypes of high-grade serous ovarian cancer.

doi:10.1186/s13073-020-00786-7

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Article

A cell-of-origin epigenetic tracer reveals clinically distinct subtypes of high-grade serous ovarian cancer.

Genome medicine - 30 Oct 2020

Lo Riso Pietro, Villa Carlo Emanuele, Gasparoni Gilles, Vingiani Andrea, Luongo Raffaele, Manfredi Anna, Jungmann Annemarie, Bertolotti Alessia, Borgo Francesca, Garbi Annalisa, Lupia Michela, Laise Pasquale, Das Vivek, Pruneri Giancarlo, Viale Giuseppe, Colombo Nicoletta, Manzo Teresa, Nezi Luigi, Cavallaro Ugo, Cacchiarelli Davide, Walter Jörn, Testa Giuseppe

Abstract excerpt

BACKGROUND: High-grade serous ovarian cancer (HGSOC) is a major unmet need in oncology. The remaining uncertainty on its originating tissue has hampered the discovery of molecular oncogenic pathways and the development of effective therapies. METHODS: We used an approach based on the retention in tumors of a DNA methylation trace (OriPrint) that distinguishes the two putative tissues of origin of HGSOC, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33121525
DOI: 10.1186/s13073-020-00786-7
PMCID: PMC7597028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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