Article

A cell-of-origin epigenetic tracer reveals clinically distinct subtypes of high grade serous ovarian cancer

2018-11-30

Abstract excerpt

High grade serous ovarian cancer (HGSOC) is a major unmet need in oncology. The persistent uncertainty on its originating tissue has contributed to hamper the discovery of oncogenic pathways and effective therapies. Here we define the DNA methylation print that distinguishes the human fimbrial (FI) and ovarian surface epithelia (OSE) and develop a robust epigenetic cell-of-origin tracer that stratifies HGSOC in FI...

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Literature Corpus work: 5ea21731-313c-5d98-b0d4-d82c7bd6e711
DOI: 10.1101/484063

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