Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The p53 endoplasmic reticulum stress-response pathway evolved in humans but not in mice via PERK-regulated p53 mRNA structures

22 Feb 2023

Abstract excerpt

Cellular stress conditions activate p53-dependent pathways to counteract the inflicted damage. To achieve the required functional diversity, p53 is subjected to numerous post-translational modifications and the expression of isoforms. Little is yet known how p53 has evolved to respond to different stress pathways. The p53 isoform p53/47 (p47 or ΔNp53) is linked to aging and neural degeneration and is expressed in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to Endoplasmic Reticulum Stress and Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36813920
DOI: 10.1038/s41418-023-01127-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The p53 endoplasmic reticulum stress-response pathway evolved in humans but not in mice via PERK-regulated p53 mRNA structuresPMID 36813920Read ↗

The Emerging Landscape of p53 Isoforms in Physiology, Cancer and Degenerative Diseases.Semantic proximity Read ↗

A cancer-associated TP53 synonymous mutation induces synthesis of the p53 isoform p53/47Semantic proximity Read ↗

Alternative Mechanisms of p53 Action During the Unfolded Protein ResponseSemantic proximity Read ↗

Protein of a thousand faces: The tumor-suppressive and oncogenic responses of p53Semantic proximity Read ↗

Stress-dependent changes in the properties of p53 complexes by the alternative translation product p53/47Semantic proximity Read ↗

The Δ133p53 Isoforms, Tuners of the p53 PathwaySemantic proximity Read ↗

Canonical and non-canonical functions of p53 isoforms: potentiating the complexity of tumor development and therapy resistanceSemantic proximity Read ↗

New Δ246p53 isoform responds to DNA damage to enhance p53 family functions in cellular senescenceSemantic proximity Read ↗

Uncovering the role of p53 splice variants in human malignancy: a clinical perspectiveSemantic proximity Read ↗

Regulation of Human p53 Activity and Cell Localization by Alternative SplicingSemantic proximity Read ↗

The Δ40p53 isoform inhibits p53-dependent eRNA transcription and enables regulation by signal-specific transcription factors during p53 activationSemantic proximity Read ↗

Surf the Post-translational Modification Network of p53 RegulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.