Article
Mapping the p53 transcriptome universe using p53 natural polymorphs.
Cell death and differentiation - 1 Apr 2014
Wang B, Niu D, Lam T H, Xiao Z, Ren E C
Abstract excerpt
The tumor suppressor p53 has defined roles in varied cellular processes including apoptosis and DNA repair. While conventional genomic approaches have suggested a large number of p53 targets, there is a need for a systematic approach to validate these putative genes. We developed a method to identify and validate p53's transcriptional behavior by utilizing 16 non-synonymous p53 single-nucleotide polymorphism...
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