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Chronic kidney disease onset, progression, and cardiovascular outcomes: proteomics informs biology and risk stratification.

Cardiovascular diabetology - 20 Jan 2026

Zhang Jijuan, Yu Hancheng, Song Xingyue, Li Xianli, Xie Jinchi, Wang Yuxiang, Li Yue, Xu Kun, Liu Gang, Liao Yunfei, Ruan Xiong-Zhong, Pan An, Geng Tingting

Abstract excerpt

BACKGROUND: Large-scale proteomics provides an opportunity to understand chronic kidney disease (CKD) and cardiovascular disease, yet research in this field is limited. This study utilized proteomics to inform biology and risk stratification for these diseases. METHODS: This cohort study included 44,779 participants free of prevalent CKD, and 3,749-4,272 participants with prevalent CKD from the UK Biobank. The...

Topics

Humans
Proteomics
Risk Assessment
Renal Insufficiency, Chronic
Disease Progression
UK Biobank
Female
Middle Aged
Biomarkers
Male
Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Time Factors

Risk Factors

Mendelian Randomization Analysis

Cardiovascular Diseases

Aged

Genetic Predisposition to Disease

Prevalence

Source

Open in PubMed Open full text

Identifiers

PMID: 41559658
DOI: 10.1186/s12933-025-03049-0
PMCID: PMC12903537

Genes

IGFBP2
POLR2F
TNFRSF10B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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