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Article

Integrative Genomics Identifies Novel Associations with APOL1 Risk Genotypes in Black NEPTUNE Subjects.

Journal of the American Society of Nephrology : JASN - 1 Mar 2016

Sampson Matthew G, Robertson Catherine C, Martini Sebastian, Mariani Laura H, Lemley Kevin V, Gillies Christopher E, Otto Edgar A, Kopp Jeffrey B, Randolph Anne, Vega-Warner Virginia, Eichinger Felix, Nair Viji, Gipson Debbie S, Cattran Daniel C, Johnstone Duncan B, O'Toole John F, Bagnasco Serena M, Song Peter X, Barisoni Laura, Troost Jonathan P, Kretzler Matthias, Sedor John R

Abstract excerpt

APOL1 variants have been associated with renal phenotypes in blacks. To refine clinical outcomes and discover mechanisms of APOL1-associated kidney injury, we analyzed clinical and genomic datasets derived from 90 black subjects in the Nephrotic Syndrome Study Network (NEPTUNE), stratified by APOL1 risk genotype. Ninety subjects with proteinuria ≥0.5 g/d were enrolled at first biopsy for primary nephrotic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26150607
DOI: 10.1681/ASN.2014111131
PMCID: PMC4769193

Genes

APOL1
CXCL11
CXCL9
MUC13
UBD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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