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Modifiable risk factors and risk of schizophrenia and bipolar disorder across severities of genetic risk.

Journal of affective disorders - 15 Aug 2026

Cui Yichen, Sun Yihan, Liu Sichen, Song Jiayi, Wang Xiaoxiao, Li Nan

Abstract excerpt

BACKGROUND: Schizophrenia (SCZ) and bipolar disorder (BD) are severe, globally prevalent mental illnesses, influenced by genetic and modifiable risk factors. The brain care score (BCS) is a validated tool comprising 12 modifiable factors across physical, lifestyle, and social-emotional domains, each linked to brain health. This study examines how BCS relates to SCZ or BD risk across different genetic risk levels,...

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Bipolar Disorder
Genetic Predisposition to Disease
Genetic Risk Score
Life Style
Risk Factors

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PMID: 41985759
DOI: 10.1016/j.jad.2026.121800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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