Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence for overlapping genetic architecture between lifestyle factors and severe mental disorders with different patterns across diagnoses.

EBioMedicine - 1 Jun 2026

Rødevand Linn, Rahman Zillur, Jaholkowski Piotr, Parker Nadine, Valdimarsdóttir Unnur Anna, Smeland Olav Bjerkehagen, Tesfaye Markos, Parekh Pravesh, Frei Oleksandr, Djurovic Srdjan, Steen Nils Eiel, Dale Anders Martin, Shadrin Alexey, Andreassen Ole Andreas

Abstract excerpt

BACKGROUND: Severe mental disorders (SMDs) are associated with unhealthy lifestyle, contributing to increased risk of comorbid cardiovascular disease. Genetic factors influence both SMDs and lifestyle behaviours, but their genetic relationships remain unclear. Here, we aimed to unravel the shared genetic architecture of SMDs and lifestyle factors. Additionally, we assessed if genetic propensity to SMDs predicts...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bipolar Disorder
Share to Body Mass Index

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Risk Score

Share to Life Style

Share to Major Depressive Disorder

Share to Mental Disorders

Share to Multifactorial Inheritance

Share to Schizophrenia

Source

Open in PubMed Open full text

Identifiers

PMID: 42202747
DOI: 10.1016/j.ebiom.2026.106304
PMCID: PMC13233568

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for overlapping genetic architecture between lifestyle factors and severe mental disorders with different patterns across diagnoses.PMID 42202747Read ↗

Modifiable risk factors and risk of schizophrenia and bipolar disorder across severities of genetic risk.Semantic proximity Read ↗

Shared Genetic Loci Between Body Mass Index and Major Psychiatric Disorders: A Genome-wide Association Study.Semantic proximity Read ↗

Divergent patterns of genetic overlap between severe mental disorders and metabolic markersSemantic proximity Read ↗

Shared genetic architecture and bidirectional clinical risks within the psycho-metabolic nexusSemantic proximity Read ↗

Sex differences in shared genetic determinants between severe mental disorders and metabolic traits.Semantic proximity Read ↗

The multivariate genetic architecture of psychiatric and insulin resistance multimorbiditySemantic proximity Read ↗

Quantifying the Relative Importance of Genetics and Environment on the Comorbidity between Mental- and Cardiometabolic Disorders: A Comprehensive Analysis of National Register Data from 17 million ScandinaviansSemantic proximity Read ↗

Phenotypically independent profiles relevant to mental health are genetically correlatedSemantic proximity Read ↗

Phenotypically independent profiles relevant to mental health are genetically correlated.Semantic proximity Read ↗

Genetic liability to physical health conditions influences comorbidities in individuals with severe mental illnessSemantic proximity Read ↗

The multivariate genetic architecture of psychiatric and insulin resistance multimorbidity.Semantic proximity Read ↗

Associations of a multidimensional polygenic sleep health score and a sleep lifestyle index with disease outcomes and their interaction in a clinical biobank.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.