Article

Considering social risk alongside genetic risk for bipolar disorder in the All of Us Research Program

2026-04-07

Abstract excerpt

Polygenic risk scores (PRS) have shown increasing utility for risk stratification across complex diseases, but for psychiatric disorders such as bipolar disorder (BD), current PRS explain only a fraction of disorder liability (∼1-9%), with predictive performance further diminished in non-European populations and real-world clinical cohorts. To explore the potential of integrating social and environmental risk fact...

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Literature Corpus work: 61aac57a-1c9c-5b92-8a20-43b067de03b8
DOI: 10.64898/2026.04.06.26349528

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