Back to search

Article

Polygenic Resilience Scores are Associated with Lower Penetrance of Schizophrenia Risk Genes, Protection Against Psychiatric and Medical Disorders, and Enhanced Mental Well-Being and Cognition

2024-06-03

Abstract excerpt

<h4>ABSTRACT</h4> In the past decade, significant advances have been made in finding genomic risk loci for schizophrenia (SCZ). This, in turn, has enabled the search for SCZ resilience loci that mitigate the impact of SCZ risk genes. Recently, we discovered the first genomic resilience profile for SCZ, completely independent from the established risk loci for SCZ. We posited that these resilience loci protect agai...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a5ffce79-4837-5f28-8168-927e76f2b32b
DOI
10.1101/2024.06.03.24308377
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Polygenic Resilience Scores are Associated with Lower Penetrance of Schizophrenia Risk Genes, Protection Against Psychiatric and Medical Disorders, and Enhanced Mental Well-Being and CognitionDOI 10.1101/2024.06.03.24308377
A polygenic resilience score moderates the genetic risk for schizophrenia: Replication in 18,090 cases and 28,114 controls from the Psychiatric Genomics Consortium.Semantic proximity
A polygenic resilience score moderates the genetic risk for schizophrenia.Semantic proximity
Genetic Risk and Resilience for Schizophrenia Stratified by Perinatal Gene Expression Predict Adult Cognitive PerformanceSemantic proximity
Modifiable risk factors and risk of schizophrenia and bipolar disorder across severities of genetic risk.Semantic proximity
Role of resilience in modifying the links between genetic propensity for mental disorders and irritability.Semantic proximity
A meta-analysis of genome-wide studies of resilience in the German population.Semantic proximity
A statistical genetic investigation of psychiatric resilience.Semantic proximity
Study protocol of the Berlin Research Initiative for Diagnostics, Genetics and Environmental Factors in Schizophrenia (BRIDGE-S).Semantic proximity
Phenotypically independent profiles relevant to mental health are genetically correlatedSemantic proximity
The relationship between shared and differentiating genetic liability for schizophrenia and bipolar disorder and cognition and educational attainment in the UK BiobankSemantic proximity
GRPa-PRS: A risk stratification method to identify genetically-regulated pathways in polygenic diseases.Semantic proximity
Polygenic resilience scores capture protective genetic effects for Alzheimer's disease.Semantic proximity
Select a neighboring publication to make it the new centre.