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Comprehensive analysis of Mycobacterium tuberculosis genomes reveals genetic variations in bacterial virulence.

Cell host & microbe - 13 Nov 2024

Worakitchanon Wittawin, Yanai Hideki, Piboonsiri Pundharika, Miyahara Reiko, Nedsuwan Supalert, Imsanguan Worarat, Chaiyasirinroje Boonchai, Sawaengdee Waritta, Wattanapokayakit Sukanya, Wichukchinda Nuanjan, Omae Yosuke, Palittapongarnpim Prasit, Tokunaga Katsushi, Mahasirimongkol Surakameth, Fujimoto Akihiro

Abstract excerpt

Tuberculosis, a disease caused by Mycobacterium tuberculosis (Mtb), is a significant health problem worldwide. Here, we developed a method to detect large insertions and deletions (indels), which have been generally understudied. Leveraging this framework, we performed a comprehensive analysis of single nucleotide variants and small and large indels across 1,960 Mtb clinical isolates. Comparing the distribution...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 39471821
DOI: 10.1016/j.chom.2024.10.004

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