Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities.

PLoS pathogens - 1 Mar 2018

Carey Allison F, Rock Jeremy M, Krieger Inna V, Chase Michael R, Fernandez-Suarez Marta, Gagneux Sebastien, Sacchettini James C, Ioerger Thomas R, Fortune Sarah M

Abstract excerpt

Once considered a phenotypically monomorphic bacterium, there is a growing body of work demonstrating heterogeneity among Mycobacterium tuberculosis (Mtb) strains in clinically relevant characteristics, including virulence and response to antibiotics. However, the genetic and molecular basis for most phenotypic differences among Mtb strains remains unknown. To investigate the basis of strain variation in Mtb, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antitubercular Agents
Share to DNA Transposable Elements

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Multiple, Bacterial

Share to Genome, Bacterial

Share to High-Throughput Nucleotide Sequencing

Share to Mycobacterium tuberculosis

Share to Tuberculosis

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 29505613
DOI: 10.1371/journal.ppat.1006939
PMCID: PMC5854444

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities.PMID 29505613Read ↗

Multiplexed Strain Phenotyping Defines Consequences of Genetic Diversity in Mycobacterium tuberculosis for Infection and Vaccination Outcomes.Semantic proximity Read ↗

Multiplexed strain phenotyping defines consequences of genetic diversity in <i>Mycobacterium tuberculosis</i> for infection and vaccination outcomesSemantic proximity Read ↗

High-throughput characterization of Mycobacterium tuberculosis gene function across diverse conditions.Semantic proximity Read ↗

Mycobacterium tuberculosis functional genetic diversity, altered drug sensitivity, and precision medicine.Semantic proximity Read ↗

Genetic Diversity in Mycobacterium tuberculosis Clinical Isolates and Resulting Outcomes of Tuberculosis Infection and Disease.Semantic proximity Read ↗

Random barcode transposon-site sequencing in <i>Mycobacterium tuberculosis</i> reveals the functions of uncharacterized genesSemantic proximity Read ↗

Identifying essential genes in Mycobacterium tuberculosis by global phenotypic profiling.Semantic proximity Read ↗

Identification of bacterial determinants of tuberculosis infection and treatment outcomes: a phenogenomic analysis of clinical strains.Semantic proximity Read ↗

Mutations in dnaA and a cryptic interaction site increase drug resistance in Mycobacterium tuberculosis.Semantic proximity Read ↗

High-throughput functional genomics: A (myco)bacterial perspective.Semantic proximity Read ↗

Effects of Host, Sample, and in vitro Culture on Genomic Diversity of Pathogenic MycobacteriaSemantic proximity Read ↗

High-throughput phenogenotyping <i>of Mycobacteria tuberculosis</i> clinical strains reveals bacterial determinants of treatment outcomesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.