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Article

Comprehensive Mapping of HIV-1 Escape from a Broadly Neutralizing Antibody.

Cell host & microbe - 14 Jun 2017

Dingens Adam S, Haddox Hugh K, Overbaugh Julie, Bloom Jesse D

Abstract excerpt

Precisely defining how viral mutations affect HIV's sensitivity to antibodies is vital to develop and evaluate vaccines and antibody immunotherapeutics. Despite great effort, a full map of escape mutants has not been delineated for an anti-HIV antibody. We describe a massively parallel experimental approach to quantify how all single amino acid mutations to HIV Envelope (Env) affect neutralizing antibody...

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Topics

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Share to Antibodies, Neutralizing
Share to env Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitope Mapping

Share to HIV Antibodies

Share to HIV Envelope Protein gp120

Share to Immune Evasion

Share to Neutralization Tests

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Source

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Identifiers

PMID: 28579254
DOI: 10.1016/j.chom.2017.05.003
PMCID: PMC5512576

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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