Article
Limited neutralizing antibody specificities drive neutralization escape in early HIV-1 subtype C infection.
PLoS pathogens - 1 Sept 2009
Moore Penny L, Ranchobe Nthabeleng, Lambson Bronwen E, Gray Elin S, Cave Eleanor, Abrahams Melissa-Rose, Bandawe Gama, Mlisana Koleka, Abdool Karim Salim S, Williamson Carolyn, Morris Lynn
Abstract excerpt
We previously showed that HIV-1 subtype C viruses elicit potent but highly type-specific neutralizing antibodies (nAb) within the first year of infection. In order to determine the specificity and evolution of these autologous nAbs, we examined neutralization escape in four individuals whose responses against the earliest envelope differed in magnitude and potency. Neutralization escape occurred in all...
Topics
- Amino Acid Motifs
- Amino Acid Sequence
- Antibodies, Neutralizing
- Antibody Diversity
- Cell Line
- Epitopes
- Female
- HIV Antibodies
- HIV Envelope Protein gp120
- HIV Infections
- HIV-1
- Host-Pathogen Interactions
- Humans