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Article

TRIM65 promotes vascular smooth muscle cell phenotypic transformation by activating PI3K/Akt/mTOR signaling during atherogenesis.

Atherosclerosis - 1 Mar 2024

Zhou Zhi-Xiang, Ma Xiao-Feng, Xiong Wen-Hao, Ren Zhong, Jiang Miao, Deng Nian-Hua, Zhou Bo-Bin, Liu Hui-Ting, Zhou Kun, Hu Heng-Jing, Tang Hui-Fang, Zheng He, Jiang Zhi-Sheng

Abstract excerpt

BACKGROUND AND AIMS: Tripartite motif (TRIM65) is an important member of the TRIM protein family, which is a newly discovered E3 ligase that interacts with and ubiquitinates various substrates and is involved in diverse pathological processes. However, the function of TRIM65 in atherosclerosis remains unarticulated. In this study, we investigated the role of TRIM65 in the pathogenesis of atherosclerosis,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38301602
DOI: 10.1016/j.atherosclerosis.2023.117430

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