Article
Variant-to-Gene-Mapping Analyses Reveal a Role for the Hypothalamus in Genetic Susceptibility to Inflammatory Bowel Disease.
Cellular and molecular gastroenterology and hepatology - 1 Jan 2021
Lasconi Chiara, Pahl Matthew C, Cousminer Diana L, Doege Claudia A, Chesi Alessandra, Hodge Kenyaita M, Leonard Michelle E, Lu Sumei, Johnson Matthew E, Su Chun, Hammond Reza K, Pippin James A, Terry Natalie A, Ghanem Louis R, Leibel Rudolph L, Wells Andrew D, Grant Struan F A
Abstract excerpt
BACKGROUND & AIMS: Inflammatory bowel disease (IBD) is a polygenic disorder characterized principally by dysregulated inflammation impacting the gastrointestinal tract. However, there also is increasing evidence for a clinical association with stress and depression. Given the role of the hypothalamus in stress responses and in the pathogenesis of depression, useful insights could be gleaned from understanding its...
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