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Article

What makes the lac-pathway switch: identifying the fluctuations that trigger phenotype switching in gene regulatory systems.

Nucleic acids research - 1 Oct 2014

Bhogale Prasanna M, Sorg Robin A, Veening Jan-Willem, Berg Johannes

Abstract excerpt

Multistable gene regulatory systems sustain different levels of gene expression under identical external conditions. Such multistability is used to encode phenotypic states in processes including nutrient uptake and persistence in bacteria, fate selection in viral infection, cell-cycle control and development. Stochastic switching between different phenotypes can occur as the result of random fluctuations in...

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Identifiers

PMID: 25245949
DOI: 10.1093/nar/gku839
PMCID: PMC4191413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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