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Article

Local gene regulation details a recognition code within the LacI transcriptional factor family.

PLoS computational biology - 11 Nov 2010

Camas Francisco M, Alm Eric J, Poyatos Juan F

Abstract excerpt

The specific binding of regulatory proteins to DNA sequences exhibits no clear patterns of association between amino acids (AAs) and nucleotides (NTs). This complexity of protein-DNA interactions raises the question of whether a simple set of wide-coverage recognition rules can ever be identified. Here, we analyzed this issue using the extensive LacI family of transcriptional factors (TFs). We searched for...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 21085639
DOI: 10.1371/journal.pcbi.1000989
PMCID: PMC2978694

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Source receipt: pubmed, retrieved 7 Sept 2026.

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