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Article

Coevolutionary methods enable robust design of modular repressors by reestablishing intra-protein interactions.

Nature communications - 22 Sept 2021

Jiang Xian-Li, Dimas Rey P, Chan Clement T Y, Morcos Faruck

Abstract excerpt

Genetic sensors with unique combinations of DNA recognition and allosteric response can be created by hybridizing DNA-binding modules (DBMs) and ligand-binding modules (LBMs) from distinct transcriptional repressors. This module swapping approach is limited by incompatibility between DBMs and LBMs from different proteins, due to the loss of critical module-module interactions after hybridization. We determine a...

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Identifiers

PMID: 34552074
DOI: 10.1038/s41467-021-25851-6
PMCID: PMC8458406

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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