Article

The genotype-phenotype landscape of an allosteric protein

2020-07-11

Abstract excerpt

Allostery is a fundamental biophysical mechanism that underlies cellular sensing, signaling, and metabolism. Quantitative methods to characterize the genotype-phenotype relationships for allosteric proteins would provide data needed to improve engineering of biological systems, to uncover the role of allosteric mis-regulation in disease, and to develop allosterically targeted drugs 1 . Here we report the large-sc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7dc95cbf-c229-5c5d-985c-a49cf356d9fb
DOI: 10.1101/2020.07.10.197574

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The genotype-phenotype landscape of an allosteric proteinDOI 10.1101/2020.07.10.197574Read

The genotype-phenotype landscape of an allosteric protein.Semantic proximity Read

Large-scale DNA-based phenotypic recording and deep learning enable highly accurate sequence-function mapping.Semantic proximity Read

Deep representation learning improves prediction of LacI-mediated transcriptional repression.Semantic proximity Read

The genetic architecture of an allosteric hormone receptor.Semantic proximity Read

Dynamics-based protein network features accurately discriminate neutral and rheostat positions.Semantic proximity Read

The Energetics of Molecular Adaptation in Transcriptional RegulationSemantic proximity Read

Engineering allostery.Semantic proximity Read

Comparison of the theoretical and real-world evolutionary potential of a genetic circuit.Semantic proximity Read

Comparison of the theoretical and real-world evolutionary potential of a genetic circuit.Semantic proximity Read

Genotype to phenotype mapping and the fitness landscape of the E. coli lac promoter.Semantic proximity Read

Mapping the phenotypic landscape of a transcriptional repressor using deep mutational scanning and growth-based quantitative sequencing.Semantic proximity Read

Epistasis and pleiotropy shape biophysical protein subspaces associated with drug resistance.Semantic proximity Read