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Acinetobacter baumannii encodes multiple mutagenically and biochemically active DNA polymerase V variants.

Nucleic acids research - 19 Mar 2026

Ojha Debika, Jaszczur Malgorzata, Pham Phuong, McDonald John P, Selod Jaan C, Woodgate Roger, Goodman Myron F

Abstract excerpt

Acinetobacter baumannii natural isolates encode multiple copies of E. coli DNA polymerase V (pol VEc) umuDC homologs, some with as many as four nonidentical umuC and three nonidentical umuD genes encoding twelve possible pol VAb variants. Here, we show that six of the twelve pol VAb drive spontaneous and methyl methanesulfonate-induced mutations when expressed in E. coli. Mutagenesis depends on co-expression with...

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Identifiers

PMID: 41954978
DOI: 10.1093/nar/gkag300
PMCID: PMC13062779

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