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Article

Critical amino acids in Escherichia coli UmuC responsible for sugar discrimination and base-substitution fidelity.

Nucleic acids research - 1 Jul 2012

Vaisman Alexandra, Kuban Wojciech, McDonald John P, Karata Kiyonobu, Yang Wei, Goodman Myron F, Woodgate Roger

Abstract excerpt

The active form of Escherichia coli DNA polymerase V responsible for damage-induced mutagenesis is a multiprotein complex (UmuD'(2)C-RecA-ATP), called pol V Mut. Optimal activity of pol V Mut in vitro is observed on an SSB-coated single-stranded circular DNA template in the presence of the β/γ complex and a transactivated RecA nucleoprotein filament, RecA*. Remarkably, under these conditions, wild-type pol V Mut...

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Identifiers

PMID: 22422840
DOI: 10.1093/nar/gks233
PMCID: PMC3401427

Genes

SSB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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