Article
Comprehensive identification of somatic nucleotide variants in human brain tissue
2020-10-10
Abstract excerpt
Post-zygotic mutations incurred during DNA replication, DNA repair, and other cellular processes lead to somatic mosaicism. Somatic mosaicism is an established cause of various diseases, including cancers. However, detecting mosaic variants in DNA from non-cancerous somatic tissues poses significant challenges, particularly if the variants only are present in a small fraction of cells. Here, the Brain Somatic Mosa...
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Identifiers and source
- Literature Corpus work
- 05b11881-1813-504a-8834-87610cf5095a
- DOI
- 10.1101/2020.10.10.332213