Origins and timing of somatic variants in the brain.

Abstract excerpt

Somatic variants accumulate in human brain cells throughout the lifespan. Variant allele fraction has traditionally been used as a proxy for both the developmental timing of somatic variants and their functional effect, based on the assumption that earlier mutations are shared by larger cell populations and therefore have greater potential for severe phenotypes. However, recent discoveries challenge this...

Topics

• Humans
• Brain
• Mutation
• Mosaicism
• Genetic Variation
• Animals