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A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons

19 Feb 2020

Abstract excerpt

BACKGROUND: Midbrain dopaminergic neurons (MDN) represent 0.0005% of the brain's neuronal population and mediate cognition, food intake, and metabolism. MDN are also posited to underlay the neurobiological dysfunction of schizophrenia (SCZ), a severe neuropsychiatric disorder that is characterized by psychosis as well as multifactorial medical co-morbidities, including metabolic disease, contributing to markedly...

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PMID: 32075678
DOI: 10.1186/s13073-020-0715-x

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