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Article

Aggregative trans-eQTL analysis detects trait-specific target gene sets in whole blood.

Nature communications - 26 Jul 2022

Dutta Diptavo, He Yuan, Saha Ashis, Arvanitis Marios, Battle Alexis, Chatterjee Nilanjan

Abstract excerpt

Large scale genetic association studies have identified many trait-associated variants and understanding the role of these variants in the downstream regulation of gene-expressions can uncover important mediating biological mechanisms. Here we propose ARCHIE, a summary statistic based sparse canonical correlation analysis method to identify sets of gene-expressions trans-regulated by sets of known trait-related...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35882830
DOI: 10.1038/s41467-022-31845-9
PMCID: PMC9325868

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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