Article

Disease-associated variants are enriched for altering cell-type-specific gene co-expression relationships

2025-09-08

Abstract excerpt

Genes act within complex regulatory networks, and genetic variants can perturb these networks by altering gene co-expression. Here, we performed co-expression quantitative trait locus (co-eQTL) mapping using single-cell RNA-seq from the sc-eQTLGen consortium (1,330 donors, >2 million cells), enabling sensitive detection and prioritization of informative variant–gene–gene triplets. We identified co-eQTLs for 398 eG...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a93129a0-8fa4-5fa6-8ee4-d913eb7478a9
DOI: 10.1101/2025.09.06.674678

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Disease-associated variants are enriched for altering cell-type-specific gene co-expression relationshipsDOI 10.1101/2025.09.06.674678Read

Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell dataSemantic proximity Read

Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data.Semantic proximity Read

Single-cell RNA sequencing identifies celltype-specific cis-eQTLs and co-expression QTLs.Semantic proximity Read

Associations of genetic variants with gene expression factors reveal biological pathways underlying complex traits.Semantic proximity Read

Gene co-expression analysis for functional classification and gene-disease predictions.Semantic proximity Read

The molecular basis, genetic control and pleiotropic effects of local gene co-expressionSemantic proximity Read

The molecular basis, genetic control and pleiotropic effects of local gene co-expression.Semantic proximity Read

Co-expression analysis reveals interpretable gene modules controlled by trans-acting genetic variants.Semantic proximity Read

<i>Trans</i> -eQTLs reveal the architecture of human gene regulatory networksSemantic proximity Read

Genome-scale mapping of variant, enhancer and gene function in primary human CD4+ T cellsSemantic proximity Read

Assigning Co-Regulated Human Genes and Regulatory Gene Clusters.Semantic proximity Read

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression.Semantic proximity Read