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Article

The genetic architecture of an allosteric hormone receptor.

Nature communications - 1 Apr 2026

Stammnitz Maximilian R, Lehner Ben

Abstract excerpt

Many proteins function as switches, transducing the concentrations of environmental chemicals into cellular responses. It is not well understood how signal processing by switches is genetically encoded. Here, using a massively parallel approach, GluePCA, we present >40,000 measurements and a complete map of how mutations alter the quantitative activation function of a receptor switch, the plant hormone sensor...

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Identifiers

PMID: 41922352
DOI: 10.1038/s41467-026-70341-2
PMCID: PMC13216263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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