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Article

Protein sequestration generates a flexible ultrasensitive response in a genetic network.

Molecular systems biology - 1 Jan 2009

Buchler Nicolas E, Cross Frederick R

Abstract excerpt

Ultrasensitive responses are crucial for cellular regulation. Protein sequestration, where an active protein is bound in an inactive complex by an inhibitor, can potentially generate ultrasensitivity. Here, in a synthetic genetic circuit in budding yeast, we show that sequestration of a basic leu...

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Identifiers

PMID: 19455136
DOI: 10.1038/msb.2009.30
PMCID: PMC2694680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19455136-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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