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Article

Epistasis facilitates functional evolution in an ancient transcription factor.

eLife - 20 May 2024

Metzger Brian P H, Park Yeonwoo, Starr Tyler N, Thornton Joseph W

Abstract excerpt

A protein's genetic architecture - the set of causal rules by which its sequence produces its functions - also determines its possible evolutionary trajectories. Prior research has proposed that the genetic architecture of proteins is very complex, with pervasive epistatic interactions that constrain evolution and make function difficult to predict from sequence. Most of this work has analyzed only the direct...

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Source

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Identifiers

PMID: 38767330
DOI: 10.7554/eLife.88737
PMCID: PMC11105156

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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