Article

Deep Mutational Scanning of the GPCR Rhodopsin Reveals Pleiotropic Mutational Effects and Their Roles in Modulating Light Sensitivity

2026-07-29

Abstract excerpt

Biophysical pleiotropy, the phenomenon in which a mutation affects multiple protein properties, underlies many genetic diseases and shapes protein evolution, yet remains poorly understood, limiting synthetic biology and therapeutic development. Although extensively studied in soluble proteins, little is known about how pleiotropic effects shaped the evolution of receptor protein functions. Here, we developed a cel...

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Literature Corpus work: 77a5cec8-35c4-587a-b9f0-b1ed08a3d326
DOI: 10.64898/2026.07.27.740619

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