Article
Slx4 and Rtt107 control checkpoint signalling and DNA resection at double-strand breaks.
Nucleic acids research - 29 Jan 2016
Dibitetto Diego, Ferrari Matteo, Rawal Chetan C, Balint Attila, Kim TaeHyung, Zhang Zhaolei, Smolka Marcus B, Brown Grant W, Marini Federica, Pellicioli Achille
Abstract excerpt
The DNA damage checkpoint pathway is activated in response to DNA lesions and replication stress to preserve genome integrity. However, hyper-activation of this surveillance system is detrimental to the cell, because it might prevent cell cycle re-start after repair, which may also lead to senescence. Here we show that the scaffold proteins Slx4 and Rtt107 limit checkpoint signalling at a persistent double-strand...
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