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Article

Mismatch type impacts interference and priming activities in the type I-E CRISPR-Cas system.

The Journal of biological chemistry - 1 May 2026

Phan Phong T, Ozturk Meric, Dougherty Elizabeth M, Ravishankar Jerusha, Xue Chaoyou, Sashital Dipali G

Abstract excerpt

Type I-E CRISPR-Cas (CRISPR associated) systems direct RNA-guided interference against foreign nucleic acids using the CRISPR RNA (crRNA)-guided Cascade complex and Cas3 helicase-nuclease. DNA targeting by Cascade-Cas3 promotes priming, a mechanism that allows for rapid acquisition of new spacers within the CRISPR array. Target mutations in the protospacer adjacent motif and protospacer adjacent motif-proximal...

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Identifiers

PMID: 41895443
DOI: 10.1016/j.jbc.2026.111401
PMCID: PMC13122317

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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