Article
Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jun 2011
Semenova Ekaterina, Jore Matthijs M, Datsenko Kirill A, Semenova Anna, Westra Edze R, Wanner Barry, van der Oost John, Brouns Stan J J, Severinov Konstantin
Abstract excerpt
Prokaryotic clustered regularly interspaced short palindromic repeat (CRISPR)/Cas (CRISPR-associated sequences) systems provide adaptive immunity against viruses when a spacer sequence of small CRISPR RNA (crRNA) matches a protospacer sequence in the viral genome. Viruses that escape CRISPR/Cas resistance carry point mutations in protospacers, though not all protospacer mutations lead to escape. Here, we show...
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