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PAM-repeat associations and spacer selection preferences in single and co-occurring CRISPR-Cas systems

30 Sept 2021

Abstract excerpt

BACKGROUND: The adaptive CRISPR-Cas immune system stores sequences from past invaders as spacers in CRISPR arrays and thereby provides direct evidence that links invaders to hosts. Mapping CRISPR spacers has revealed many aspects of CRISPR-Cas biology, including target requirements such as the protospacer adjacent motif (PAM). However, studies have so far been limited by a low number of mapped spacers in the...

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PMID: 34593010
DOI: 10.1186/s13059-021-02495-9

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