Article

Identification of spacer and protospacer sequence requirements in the <i>Vibrio cholerae</i> Type I-E CRISPR/Cas System

2020-08-10

Abstract excerpt

The prokaryotic adaptive immune system CRISPR/Cas serves as defense against bacteriophage and invasive nucleic acid. A Type I-E CRISPR/Cas system has been detected in classical biotype isolates of Vibrio cholerae , the causative agent of the disease cholera. Experimental characterization of this system revealed a functional immune system that operates using a 5’-TT-3’ protospacer-adjacent motif (PAM) for interfer...

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Literature Corpus work: 80f30dd3-e131-5e51-9c3b-30cadc1896a7
DOI: 10.1101/2020.08.09.243105

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