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Article

Degenerate target sites mediate rapid primed CRISPR adaptation.

Proceedings of the National Academy of Sciences of the United States of America - 22 Apr 2014

Fineran Peter C, Gerritzen Matthias J H, Suárez-Diez María, Künne Tim, Boekhorst Jos, van Hijum Sacha A F T, Staals Raymond H J, Brouns Stan J J

Abstract excerpt

Prokaryotes encode adaptive immune systems, called CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR associated), to provide resistance against mobile invaders, such as viruses and plasmids. Host immunity is based on incorporation of invader DNA sequences in a memory locus (CRISPR), the formation of guide RNAs from this locus, and the degradation of cognate invader DNA (protospacer)....

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Share to Base Pair Mismatch
Share to Clustered Regularly Interspaced Short Palindromic Repeats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24711427
DOI: 10.1073/pnas.1400071111
PMCID: PMC4000823

Genes

PAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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