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Article

Two distinct DNA binding modes guide dual roles of a CRISPR-Cas protein complex.

Molecular cell - 2 Apr 2015

Blosser Timothy R, Loeff Luuk, Westra Edze R, Vlot Marnix, Künne Tim, Sobota Małgorzata, Dekker Cees, Brouns Stan J J, Joo Chirlmin

Abstract excerpt

Small RNA-guided protein complexes play an essential role in CRISPR-mediated immunity in prokaryotes. While these complexes initiate interference by flagging cognate invader DNA for destruction, recent evidence has implicated their involvement in new CRISPR memory formation, called priming, against mutated invader sequences. The mechanism by which the target recognition complex mediates these disparate...

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Identifiers

PMID: 25752578
DOI: 10.1016/j.molcel.2015.01.028
PMCID: PMC4475636

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PAM

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